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Exercise-based rehabilitation with or without blood flow restriction in individuals with heart failure: Protocol for the rehab-washout HF trial.

Silva RC, Miranda TM, Jesus Almeida L, Carvalho Fiusa V, Vaz MA, Sousa LL et al. · JSAMS plus · 2026

This is a study protocol (no results yet) for a trial comparing four months of conventional moderate-to-heavy resistance training (60-80% of 1RM) against low-load training with blood flow restriction (20-30% of 1RM at 50% arterial occlusion pressure) in 52 people with heart failure. It will track a blood marker of cardiac strain (NT-proBNP), quality of life, heart function on echo, functional capacity, and clinical events, plus eight months of follow-up.
Abstract (source)

Background: Heart failure (HF) significantly reduces functional capacity and quality of life in patients classified as New York Heart Association (NYHA) functional class II-III. While cardiopulmonary rehabilitation (CR) is beneficial, innovative strategies are required to improve accessibility and effectiveness for individuals unable to tolerate high hemodynamic loads.

Aims: To compare the effects of conventional moderate-to-high intensity resistance training (CRT) versus low-load resistance training combined with blood flow restriction (BFRRT) on clinical, functional, and biochemical outcomes in HF patients.

Methods: and analysis This randomized, prospective, parallel-group clinical trial will include 52 patients (NYHA II-III) allocated into CRT (60-80% 1RM) or BFRRT (20-30% 1RM, calibrated at 50% arterial occlusion pressure) groups. The supervised intervention lasts 4 months, with an 8-month post-intervention follow-up. The primary outcome is the change in serum NT-proBNP levels. Secondary outcomes include quality of life, echocardiographic ventricular function, functional capacity, and clinical events. Advanced statistical models and exploratory machine learning analyses with k-fold cross-validation will be utilized for predictive modeling and exploring personalized medicine strategies. Implications The REHAB-WASHOUT HF trial

aims to establish an effective, safe, and accessible therapeutic approach for HF rehabilitation, potentially enhancing clinical outcomes and guiding personalized prescriptive strategies in cardiovascular rehabilitation. Ethics and registration Approved by the local institutional review board (No. 5.848.965; CAAE 64955022.9.1001.0029). Trial registration: RBR-5y8k7d7.

Randomized controlled trialProgramming & Periodization
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