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Does the choice of inspiratory muscle training modality affect respiratory and peripheral muscle function in chronic kidney disease?

Firat M, Saglam M, Calik E, Inal-Ince D, Ardali-Duzgun S, Yildirim T et al. · International urology and nephrology · 2026

This randomized trial had 38 people with non-dialysis chronic kidney disease do 10 weeks of either "fundamental" breathing-muscle training, "functional" breathing-muscle training (breathing training combined with movement), or no training, all delivered remotely. Both training groups beat the control group on breathing muscle strength and pressure, diaphragm mobility, quadriceps and grip strength, trunk endurance, and 6-minute walk distance, and the authors concluded functional IMT may add extra benefit for inspiratory endurance and musculoskeletal function.
Takeaway: Consider adding inspiratory muscle training—ideally combined with movement—to a remote exercise routine if you have chronic kidney disease, with clinician guidance.
Abstract (source)

Purpose: Chronic kidney disease (CKD) can impair respiratory, muscle, and functional capacity. This randomized controlled trial investigated the effects of fundamental and functional inspiratory muscle training (IMT) delivered via telerehabilitation in patients with non-dialysis CKD.

Methods: Sixty patients were randomized to fundamental IMT, functional IMT, or control groups. Thirty-eight participants completed the study and were analyzed: fundamental IMT (n = 13), functional IMT (n = 13), and control (n = 12). Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP), strength index (S-Index), peak inspiratory flow (PIF), respiratory muscle endurance, diaphragmatic thickness and mobility, quadriceps muscle strength (QMS) and hand grip strength (HGS), trunk muscle endurance (partial sit-ups, prone, side, and pelvic bridge tests) and 6-minute walk test (6MWT) were assessed before and after 10 weeks.

Results: Compared with the control group, both intervention groups showed significant increases in MIP, MEP, S-Index, PIF, diaphragmatic mobility, QMS, HGS, trunk muscle endurance, and 6MWT distance (p 0.05).

Conclusion: Functional IMT delivered via telerehabilitation may provide additional benefits over fundamental IMT for inspiratory muscle endurance and musculoskeletal function in patients with non-dialysis CKD. Both IMT modalities improved functional capacity compared with control. These

Findings: support the potential integration of functional IMT into telerehabilitation-based rehabilitation programs for CKD.

Randomized controlled trialEndurance & Cardiovascular
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