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A Review of Rejuvenation Strategies Targeting Mesenchymal Stem Cell Senescence and Their Impact on Bone Health and Regeneration

D Heinrichs, Rebekah M. Samsonraj · Current Osteoporosis Reports · 2026

This review looks at how aging causes mesenchymal stem cells (the cells that help build and repair bone) to become 'senescent' or worn out, and how that contributes to age-related bone loss. It surveys strategies being researched to rejuvenate these cells, including senolytic drugs, biomaterials and nanovesicles, and physical exercise, noting that clinical trials are underway but that these approaches are still in development.
Takeaway: Keep exercising, since physical activity is among the strategies being studied for keeping bone-building stem cells youthful.
Abstract (source)

Purpose: OF REVIEW: The

purpose of this article is to emphasize the critical role aging and senescence plays on mesenchymal stem cell (MSC) functionality and its influence on bone health. This review also highlights recent advancements in strategies to rejuvenate senescent MSCs to aid in delaying or preventing age-related illnesses associated with bone loss. RECENT

Findings: Studies have expanded upon many established rejuvenation strategies including senolytic agents, drugs used to selectively eliminate senescent cells, and targeted inhibitors to the secretory profile of senescent cells. New routes for MSC rejuvenation including nanoplatform targets such as biomaterials, nanovesicles, and physical exercise are showing promise for future clinical applications. Ongoing clinical trials are progressing towards rejuvenation therapies that delay age-induced bone loss. This review provides an overview of the current research landscape into rejuvenation of senescent MSCs to combat bone loss due to age and highlights new platforms and strategies for rejuvenation that could have clinical relevance.

Primary studyOpen accessResistance Training & Hypertrophy
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