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Central and Peripheral Fatigue Following Free-Weight and Smith Machine Squat Training: Neuromuscular Efficiency in Knee Extensors.

Marcos-Frutos D, Martos-Arregui A, García-Ramos A, Márquez G. · International journal of sports physiology and performance · 2026

This study compared fatigue responses when trained men performed squat workouts using either free weights or a Smith machine, measuring mechanical fatigue, how hard the sets felt, and neural fatigue using specialized testing. The Smith machine produced similar mechanical and perceptual fatigue as free weights, but caused less neuromuscular fatigue in the knee extensors despite producing similar strength training stimulus.
Takeaway: Consider using a Smith machine for squats if you want to reduce nervous system fatigue while still building strength, especially if you're managing recovery or training volume.
Abstract (source)

Background: Free-weight (FW) and machine-guided exercises have been shown to promote similar strength and hypertrophy adaptations. Under such conditions, the exercise modality that induces less fatigue may be considered more efficient and advantageous for training prescription.

Purpose: To compare the mechanical, perceptual, and neuromuscular fatigue induced by a squat strength training session performed with FW or a Smith machine (SM).

Methods: Nineteen young strength-trained men (age = 23.5 [3.8] y; strength training experience = 4.7 [2.4] y) completed 2 sessions in a randomized order, each involving 4 sets of 9 repetitions at 70% 1-repetition maximum and differing only in the squat modality (FW or SM). Mechanical fatigue was assessed by velocity loss during training and by pre-post changes in isometric force; perceptual fatigue was assessed by subjectively estimated repetitions in reserve and neuromuscular fatigue (ie, peripheral and central fatigue components) via the twitch interpolation technique during isometric unilateral knee extension.

Results: No fatigue differences were observed for velocity loss or perceptual fatigue variables (P = .136-.313). In contrast, most peripheral and central fatigue variables showed significant posttraining differences (P

Conclusions: Given the comparable adaptations typically reported for FW and SM exercises, the SM squat may represent a more efficient option for promoting strength adaptations while minimizing neuromuscular fatigue in knee extensors.

Randomized controlled trialResistance Training & Hypertrophy
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