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Effects of Different Exercise Modalities on Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer Patients.

Wang Z, Wu X, Shen Y, Liu H, Xu X, Kang J et al. · Pain management nursing : official journal of the American Society of Pain Management Nurses · 2026

This study compared different exercise types (aerobic, resistance, or combined) versus no exercise in 68 breast cancer patients experiencing chemotherapy-induced peripheral neuropathy over 8 weeks. Both aerobic and resistance training significantly improved nerve symptoms and quality of life, with combined exercise showing the best overall results for symptom relief, muscle strength, and wellbeing.
Takeaway: Include both aerobic and resistance training in your exercise routine if you're managing chemotherapy-related nerve damage, as combined exercise produced better outcomes than either type alone.
Abstract (source)

Purpose: To investigate effects of different exercise modalities on chemotherapy‑induced peripheral neuropathy (CIPN) and quality of life in breast cancer patients, and identify the optimal exercise rehabilitation protocol.

Design: This study is a single-center randomized controlled trial.

Methods: This randomized controlled trial enrolled 68 breast cancer patients with CIPN, randomly assigning them to a control group, aerobic exercise group, resistance training group, and combined exercise group for an 8-week intervention. Outcomes included foot vibration perception, lower limb muscle strength, and quality of life.

Results: After 8 weeks of intervention, both aerobic exercise and resistance training significantly improved CIPN symptoms (p .05).

Conclusions: Exercise therapy is safe and effective in relieving symptoms, enhancing muscle strength, and improving quality of life, with combined exercise showing optimal effects for clinical application. Clinical implication This study offers references for clinical nonpharmacological rehabilitation of CIPN. Tailored combined aerobicresistance exercise may be considered. Integrating subjective scales with

Objective: functional indicators and monitoring lymphedema risks helps formulate holistic rehabilitation strategies.

Randomized controlled trialResistance Training & Hypertrophy
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